Caspase-free mitotic death
نویسندگان
چکیده
منابع مشابه
Caspase-free mitotic death
Caspase-free mitot ic death O n page 283, Niikura et al. document a new way for abnormal cells to kill themselves. The mechanism might weed out potentially cancerous cells in which the spindle checkpoint has malfunctioned. Before progressing through mitosis, cells verify that the microtubules of the spindle apparatus are properly attached to the chromosomes. If they aren’t, the spindle checkpoi...
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The spindle checkpoint that monitors kinetochore-microtubule attachment has been implicated in tumorigenesis; however, the relation between the spindle checkpoint and cell death remains obscure. In BUB1-deficient (but not MAD2-deficient) cells, conditions that activate the spindle checkpoint (i.e., cold shock or treatment with nocodazole, paclitaxel, or 17-AAG) induced DNA fragmentation during ...
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Histone deacetylases (HDACs) are known to play a central role in the regulation of several cellular properties interlinked with the development and progression of cancer. Recently, HDAC1 has been reported to be overexpressed in hepatocellular carcinoma (HCC), but its biological roles in hepatocarcinogenesis remain to be elucidated. In this study, we demonstrated overexpression of HDAC1 in a sub...
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We have examined the relationship between chemotherapy-induced mitotic catastrophe and cell death by apoptosis in both wild-type and p53(-/-) HCT116 human colon carcinoma cells treated with nanomolar concentrations of paclitaxel (PTX), a drug that acts on tubulin altering the normal development of mitosis. After treatment, HCT116 cells entered mitosis regardless of the presence of functional p5...
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In This Issue In This Issue ROCK and Rho will never Dia irectional migration of a cell requires both lamellipodia formation at the leading edge and actomyosin contraction within the tail. New results from Tsuji et al. (page 819) indicate that Rho may mediate both tasks, and that these two arms of Rho signaling are antagonistic. Rho signaling is known to mediate the formation of stress fibers, s...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1782iti1